Biotechnology and Bioengineering

Biotechnology and Bioengineering News -- ScienceDaily Biotechnology and bioengineering research news.

  • Far-red fluorescent silk can kill harmful bacteria as biomedical and environmental remedy
    on April 19, 2018 at 5:10 pm

    A silk hybrid material attacks bacteria when illuminated by a green light, thanks to a far-red fluorescent protein researchers transferred to its genetic makeup. […]

  • Breakthrough brings gene-editing medicine one step closer to patient applications
    on April 13, 2018 at 6:45 pm

    Researchers have discovered a way to greatly improve the accuracy of gene-editing technology by replacing the natural guide molecule it uses with a synthetic one called a bridged nucleic acid, or BNA. The research promises to bring the technology much closer to therapeutic reality. […]

  • Pig model of Huntington's offers advantages for testing treatments
    on March 29, 2018 at 6:10 pm

    A team of scientists has established a 'knock in' pig model of Huntington's disease (HD), an inherited neurodegenerative disease, anticipated to be useful for testing treatments. […]

  • Let them eat xylose: Yeast engineered to grow efficiently on novel nutrients
    on March 26, 2018 at 1:03 pm

    Researchers have created a genetically modified yeast that can more efficiently consume a novel nutrient, xylose, enabling the yeast to grow faster and to higher cell densities, raising the prospect of a significantly faster path toward the design of new synthetic organisms for industrial applications, according to a new study. […]

  • New innovations in cell-free biotechnology
    on March 23, 2018 at 5:27 pm

    A new platform to conduct cell-free protein synthesis could lead to improved quality of manufactured protein therapeutics and biomaterials. […]

  • Using light to turn yeast into biochemical factories
    on March 22, 2018 at 10:13 pm

    Researchers have used a combination of light and genetic engineering to controlling the metabolism, or basic chemical process, of a living cell. Building on techniques that already have transformed the field of neuroscience, the researchers used light to control genetically-modified yeast and increase its output of commercially valuable chemicals. […]

  • Making intricate images with bacterial communities
    on March 19, 2018 at 11:00 pm

    A technique for growing sticky films of bacteria into elaborate microscopic images could reveal how potentially dangerous biofilms grow and transmit antibiotic resistance, and could lead to novel biomaterials or synthetic microbial communities. […]

  • Engineers create most efficient red light-activated optogenetic switch for mammalian cells
    on March 13, 2018 at 12:41 pm

    Researchers have developed a light-activated switch that can turn genes on and off in mammalian cells. This is the most efficient so-called 'optogenetic switch' activated by red and far-red light that has been successfully designed and tested in animal cells -- and it doesn't require the addition of sensing molecules from outside the cells. […]

  • Gene knockout using new CRISPR tool makes mosquitoes highly resistant to malaria parasite
    on March 8, 2018 at 7:30 pm

    Deleting a single gene from mosquitoes can make them highly resistant to the malaria parasite and thus much less likely to transmit the parasite to humans, according to a new article. […]

  • Bioengineering team's 'circuit' work may benefit gene therapy
    on March 6, 2018 at 4:57 pm

    Researchers have designed genetic 'circuits' out of living cellular material in order to gain a better understanding of how proteins function, with the goal of making improvements. […]

  • Drug-producing bacteria possible with synthetic biology breakthrough
    on March 5, 2018 at 6:04 pm

    Bacteria could be programmed to efficiently produce drugs, thanks to breakthrough research into synthetic biology using engineering principles. […]

  • Mitochondria-to-nucleus messenger protein discovered
    on March 1, 2018 at 7:41 pm

    Researchers have identified a protein, G-Protein Pathway Suppressor 2 (GPS2), that moves from a cell's mitochondria to its nucleus in response to stress and during the differentiation of fat cells. While proteins with similar functions had previously been found in yeast and worms, this is first direct messenger discovered in the cells of mammals. […]

  • Scientists improve DNA transfer in gene therapy
    on February 15, 2018 at 3:57 pm

    Parkinson's disease, Huntington's disease, cystic fibrosis - these and many other fatal hereditary human diseases are genetically transmitted. Many cancers and cardiovascular diseases are also caused by genetic defects. Gene therapy is a promising possibility for the treatment of these diseases. With the help of genetically modified viruses, DNA is introduced into cells in order to repair or replace defective genes. By using this method, scientists have discovered a quicker and more efficient treatment for the cells. […]

  • Mouse study adds to evidence linking gut bacteria and obesity
    on February 12, 2018 at 3:06 pm

    A new study of mice with the rodent equivalent of metabolic syndrome has added to evidence that the intestinal microbiome -- a 'garden' of bacterial, viral and fungal genes -- plays a substantial role in the development of obesity and insulin resistance in mammals, including humans. […]

  • Efficient technique discovered for isolating embryonic stem cells in cows
    on February 9, 2018 at 10:05 pm

    Scientists have developed a highly efficient method of isolating embryonic stem cells in cows. Producing embryonic stem cells from large livestock species like cattle is important for genetic testing, genome engineering, and studying human disease. […]

  • Workbench for virus design
    on February 6, 2018 at 3:03 pm

    Researchers have developed a technology platform that allows them to systematically modify and customize bacteriophages. This technology is a step towards making phage therapies a powerful tool for combating dangerous pathogens. […]

  • New genome-editing method 'cuts back' on unwanted genetic mutations
    on February 5, 2018 at 2:29 pm

    Gene therapy can potentially correct genetic disorders by directly editing defective genes. CRISPR-Cas9 is a popular gene-editing technology whose clinical utility is limited by its tendency to produce unintended genetic errors. Researchers centered at Osaka University developed a modified CRISPR-Cas9 system that uses single-stranded nicking, rather than DNA cleavage, to generate highly precise changes to a target gene. The technique offers a more accurate and safer editing strategy for future gene therapy applications. […]

  • Solving the puzzle of multicellularity
    on February 2, 2018 at 4:26 pm

    One of the big evolutionary questions in life is how and why single cell organisms organized themselves to live in a group, thereby forming multicellular life forms. Scientists have answered at least part of this question, by decoding the genomic sequence of one of the simplest of all multicellular organisms -- the four-celled alga Tetrabaena socialis. […]

  • Bacterial immune systems take the stage
    on January 25, 2018 at 7:08 pm

    Researchers now understand that most microorganisms have sophisticated immune systems of which CRISPR is just one element; but there has been no good way to identify these systems. In a massive, systematic study, scientists have now revealed the existence of 10 previously unknown immune defense mechanisms in bacteria. […]

  • Digging deep into distinctly different DNA
    on January 22, 2018 at 8:07 pm

    A new discovery has deepened our understanding of the genetic mutations that arise in different tissues, and how these are inherited. Researchers found the rates of genetic mutations in mitochondrial DNA vary across differing tissue types, with the highest rate occurring in reproductive cells. […]

  • Lab-made hormone may reveal secret lives of plants
    on January 22, 2018 at 8:06 pm

    A new synthetic hormone promises to tease apart the many different roles of the plant hormone auxin and could lead to a new way to ripen fruit. […]

  • Researchers create first stem cells using CRISPR genome activation
    on January 18, 2018 at 9:24 pm

    In a scientific first, researchers have turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important insights into the cellular reprogramming process. […]

  • Biologists create toolkit for tuning genetic circuits
    on January 11, 2018 at 4:53 pm

    Scientists have created a toolkit for synthetic biologists who need to precisely tune the input and output levels of genetic circuits. […]

  • One-step production of aromatic polyesters by E. coli strains
    on January 9, 2018 at 3:47 pm

    Systems metabolic engineers defined a novel strategy for microbial aromatic polyesters production fused with synthetic biology from renewable biomass. The team produced aromatic polyesters from Escherichia coli (E. coli) strains by applying microbial fermentation, employing direct microbial fermentation from renewable feedstock carbohydrates. […]

  • Engineers hack cell biology to create 3-D shapes from living tissue
    on December 28, 2017 at 6:20 pm

    Many of the complex folded shapes that form mammalian tissues can be explained with very simple instructions, bioengineers report. By patterning mechanically active mouse or human cells to thin layers of extracellular fibers, the researchers could create bowls, coils, and ripples out of living tissue. The cells collaborated mechanically through a web of these fibers to fold themselves up in predictable ways, mimicking natural developmental stages. […]

  • First-of-its-kind chemical oscillator offers new level of molecular control
    on December 14, 2017 at 11:18 pm

    Researchers successfully constructed a first-of-its-kind chemical oscillator that uses DNA components. DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors. […]

  • Synthetic protein packages its own genetic material and evolves
    on December 14, 2017 at 2:23 pm

    Scientists have created computationally designed protein assemblies, that display some functions normally associated with living things, in the search for ways to transport therapeutic cargo into specific types of cells without using viruses as vehicles. These encapsulate their own RNA genomes and evolve new traits in complex environments. They are synthetic versions of the protein shells that viruses use to protect and deliver materials. The synthetic proteins evolved better RNA packaging, resistance against degrading enzymes in blood and longer circulation time. […]

  • Bacteria development marks new era in cellular design
    on December 11, 2017 at 7:03 pm

    Scientists have built a miniature scaffold inside bacteria that can be used to bolster cellular productivity, with implications for the next generation of biofuel production. Because there is a growing need for agricultural or renewable production of biofuels and other commodity chemicals to move away from fossil fuels, scientists have long sought to enhance the internal organization of bacteria and improve the efficiency of the cells for making nutrients, pharmaceuticals and chemicals. […]

  • Algae could feed and fuel planet with aid of new high-tech tool
    on December 7, 2017 at 7:18 pm

    Vast quantities of medicines and renewable fuels could be produced by algae using a new gene-editing technique, a study suggests. […]

  • CRISPR-Cas9 technique targeting epigenetics reverses disease in mice
    on December 7, 2017 at 7:17 pm

    Scientists report a modified CRISPR-Cas9 technique that alters the activity, rather than the underlying sequence, of disease-associated genes. The researchers demonstrate that this technique can be used in mice to treat several different diseases. […]