Molecular Biology

Molecular Biology News -- ScienceDaily Molecular biology. Read the latest research on molecular biology or search thousands of news articles with images from leading universities and research institutes.

  • DNA: Supercoiling pushes molecular handcuffs along chromatin fibres
    on December 14, 2017 at 3:13 pm

    As it squeezes down the chromatin fiber, the cohesin protein complex extrudes a growing loop of DNA -- a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of the protein? A team of scientists has found that the driving force could be the supercoiling of upstream DNA. Their research is thereby adding a key piece to the puzzle of gene expression regulation. […]

  • Ancient genetic mutation helps explain origin of some human organs
    on December 14, 2017 at 3:08 pm

    A genetic mutation that occurred over 700 million years ago may have contributed to the development of certain organs in human beings and other vertebrates. This change, a random error in the evolutionary process, facilitated the connection of the gene networks involved in animal embryogenesis. […]

  • Synthetic protein packages its own genetic material and evolves
    on December 14, 2017 at 2:23 pm

    Scientists have created computationally designed protein assemblies, that display some functions normally associated with living things, in the search for ways to transport therapeutic cargo into specific types of cells without using viruses as vehicles. These encapsulate their own RNA genomes and evolve new traits in complex environments. They are synthetic versions of the protein shells that viruses use to protect and deliver materials. The synthetic proteins evolved better RNA packaging, resistance against degrading enzymes in blood and longer circulation time. […]

  • Microbes help turn Greek yogurt waste into fuel
    on December 13, 2017 at 7:37 pm

    Consumers across the world enjoy Greek yogurt for its taste, texture, and protein-packed punch. Reaching that perfect formula, however, generates large volumes of food waste in the form of liquid whey. Now researchers have found a way to use bacteria to turn the leftover sugars and acids from Greek yogurt into molecules that could be used in biofuels or safe feedstock additives. […]

  • Immune cells turn back time to achieve memory
    on December 13, 2017 at 7:36 pm

    What distinguishes memory CD8 T cells from untrained naive cells is that they can respond rapidly, within minutes or hours. The new research illuminates how they do it -- their genes are poised to respond, even years after initial activation. […]

  • Cells sense their environment to explore it
    on December 13, 2017 at 5:58 pm

    The process through which cells are able to sense their environment is regulated by force detection, concludes new research. […]

  • Converting waste water from dairies to animal feed and aviation fuel
    on December 13, 2017 at 5:49 pm

    Scientists have developed a bioprocess that enables conversion of acid whey, a dairy by-product, without the use of additional chemicals. Scientists used microbiome cultures similar to those in the human gut. The new bio-oil can be used in animal feed or, after further refinement, as a fuel for airplanes. […]

  • Structure of molecular light switch -- channelrhodopsin -- determined
    on December 13, 2017 at 4:58 pm

    Researchers discover structure and mechanism of action of molecular light switch, paving the way for new applications. […]

  • Bacterial control mechanism for adjusting to changing conditions
    on December 13, 2017 at 4:58 pm

    A fundamental prerequisite for life on earth is the ability of living organisms to adapt to changing environmental conditions. Physicists have now determined that the regulation mechanisms used by bacteria to adapt to different environments are based on a global control process that can be described in a single equation. […]

  • New active ingredients from the toolbox: Design, biotechnological production of new peptide-based...
    on December 13, 2017 at 3:49 pm

    Microorganisms often produce natural products in a step-by-step manner similar to an assembly line. Examples of such enzymes are non-ribosomal peptide synthetases. Researchers have now succeeded in designing these enzymes in such a way that they can produce completely new natural products. […]

  • Important new aspects are revealed about the control of cell division
    on December 12, 2017 at 5:54 pm

    Experts have published a new study on the mechanisms that regulate cell division and guarantee the correct distribution of chromosomes during this process. In particular, they especially highlight the fundamental role that an organelle, specifically the nucleolus, plays in the coordination of these processes. […]

  • Visualizing single molecules in whole cells with a new spin
    on December 12, 2017 at 5:54 pm

    Scientists have adapted DNA-PAINT technology to microscopes that are widespread among cell biology laboratories, called confocal microscopes, and that are used by researchers to image whole cells and thicker tissues at lower resolution. They have demonstrated that the method can visualize a variety of different molecules, including combinations of different proteins, RNAs and DNA throughout the entire depth of whole cells at super-resolution. […]

  • Teaching antibiotics to be more effective killers
    on December 12, 2017 at 2:10 pm

    Research suggests bond duration, not bond tightness, may be the most important differentiator between antibiotics that kill bacteria and antibiotics that only stop bacterial growth. […]

  • Quality control is vital for the energy production of cells
    on December 12, 2017 at 12:27 am

    Researchers have uncovered a mitochondrial error-correction mechanism, which is vital for the construction of the mitochondrial respiratory chain and the energy production of cells. […]

  • Protein Daple coordinates single-cell and organ-wide directionality in the inner ear
    on December 11, 2017 at 8:28 pm

    Sensory hair cells in the inner ear combine into hair bundles to convert sound waves into electrical signals. Both single-cell and organ-wide directionality are critical for hearing, but these two levels of organization are controlled by largely distinct molecular mechanisms during inner ear development. Researchers have identified a protein, Daple, that interacts with both systems and is a promising candidate to coordinate single cell and organ-wide directionality. […]

  • How Zika virus induces congenital microcephaly
    on December 11, 2017 at 7:08 pm

    Epidemiological studies show that in utero fetal infection with the Zika virus (ZIKV) may lead to microcephaly, an irreversible congenital malformation of the brain characterized by an incomplete development of the cerebral cortex. However, the mechanism of Zika virus-associated microcephaly remains unclear. Scientists have now identified a specific mechanism leading to this microcephaly. […]

  • Bacteria development marks new era in cellular design
    on December 11, 2017 at 7:03 pm

    Scientists have built a miniature scaffold inside bacteria that can be used to bolster cellular productivity, with implications for the next generation of biofuel production. Because there is a growing need for agricultural or renewable production of biofuels and other commodity chemicals to move away from fossil fuels, scientists have long sought to enhance the internal organization of bacteria and improve the efficiency of the cells for making nutrients, pharmaceuticals and chemicals. […]

  • Yeast can be engineered to create protein pharmaceuticals
    on December 11, 2017 at 2:17 pm

    It took several years, but a research team has finally succeeded in mapping out the complex metabolism of yeast cells. The breakthrough means a huge step forward in the potential to more efficiently produce protein therapies for diseases such as cancer. […]

  • Epigenetic orchestrator of pancreatic cancer cells
    on December 11, 2017 at 2:08 pm

    Genetech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells' chromatin. The study suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect against this deadly form of cancer. […]

  • Internal forces directing cell migration are revealed by live-cell microscopy
    on December 11, 2017 at 2:07 pm

    New research show how cells respond to internal forces when they orient, gain traction, and migrate in a specific direction. […]

  • Scientists channel graphene to understand filtration, ion transport into cells
    on December 8, 2017 at 8:23 pm

    Nanometer-scale pores etched into layers of graphene can provide a simple model for the complex operation of ion channels, researchers have demonstrated. […]

  • Toxoplasmosis: How a cat parasite exploits immune cells to reach the brain
    on December 8, 2017 at 2:59 pm

    Scientists have previously shown that a parasite from cats can infect people's brain and affect our behaviour. Now, researchers at Stockholm University have discovered how the parasite takes control of our cells. […]

  • Acrobatic duo in the cells
    on December 8, 2017 at 1:53 pm

    Just like an acrobatic duo, some proteins lend each other stability. Researchers have discovered that the protein 'Trigger factor' recognizes a partner by unstable, flexible domains, to then together form a stable protein duo. […]

  • Suite of papers shed light on decade-long stem cell mystery
    on December 7, 2017 at 7:18 pm

    A series of studies has shed light on vital, yet previously unclear, aspects of cell reprogramming. […]

  • CRISPR-Cas9 technique targeting epigenetics reverses disease in mice
    on December 7, 2017 at 7:17 pm

    Scientists report a modified CRISPR-Cas9 technique that alters the activity, rather than the underlying sequence, of disease-associated genes. The researchers demonstrate that this technique can be used in mice to treat several different diseases. […]

  • The unique pentraxin-carbonic anhydrase protein regulates the ability of fish to swim
    on December 7, 2017 at 7:16 pm

    A study has shown that carbonic anhydrase VI (CA VI) is present in some species as a combination of two proteins. […]

  • A spring-loaded sensor for cholesterol in cells
    on December 7, 2017 at 6:22 pm

    New research explains how an enzyme acts as a kind of thermostat that responds to and adjusts levels of cholesterol in the cell. This insight could lead to new strategies for combating high cholesterol. […]

  • Healthy mitochondria could stop Alzheimer's
    on December 6, 2017 at 6:25 pm

    Using a bioinformatics and experimental approach, scientists have found that rendering mitochondria resistant to damage can halt diseases caused by amyloid toxicity, such as Alzheimer's disease. […]

  • The world's smallest Mona Lisa
    on December 6, 2017 at 6:20 pm

    New techniques in DNA self-assembly allow researchers to create the largest to-date customizable patterns with nanometer precision on a budget. […]

  • Invasive 'supervillain' crab can eat through its gills
    on December 6, 2017 at 5:25 pm

    Invasive green shore crabs can 'eat' by absorbing nutrients across its gills -- the first demonstration of this ability in crustaceans -- scientists have found. […]